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Gprc5a depletion enhances the risk of smoking-induced lung tumorigenesis and mortality

Initial pathway-level interrogation of the metabolomics dataset using the MetaboAnalyst 6.0 platform and the MetPa enrichment tool revealed prominent alterations in bioenergetic circuits, including the TCA cycle, glycolysis/gluconeogenesis, pyruvate metabolism, and fatty acid elongation (Fig

Nevertheless, source-specific differences in secretory profile, immunomodulation and in-vivo persistence persist

These pharmacokinetic features, characterized by rapid clearance and short systemic exposure, further challenge their preclinical-to-clinical applicability

Guo et al., 2016) and FMN (Bessey et al., 1956