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Beyond engineering live probiotics, their derivativessuch as exosomes and membrane vesiclesprovide platforms for delivering nucleic acid therapeutics and nanozymes

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IGF-1 is necessary for MSC differentiation, not recruitment during bone remodeling To examine the mechanism of the reduced bone mass in the MSC- Igf1r / mice, we performed immunohistochemical staining for Osterix and Osteocalcin to label osteoprogenitors and mature osteoblasts, respectively in mouse femora