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Pyruvate molecules produced by glycolysis are actively transported across the inner mitochondrial membrane, and into the matrix

2024 Feb;27:E221-9

It stimulates the release of growth hormone from the pituitary gland without significantly affecting cortisol or prolactin levels

These structural changes are underpinned by activation of the PGC-1/fibronectin type III domain-containing protein 5 (FNDC5)/BDNF axis, with prolonged endurance training boosting BDNF synthesis across multiple brain regions [29]