Often referred to as the "master antioxidant," glutathione plays a crucial role in maintaining cellular health, detoxification processes, and immune function
it's a rule written in the unforgiving language of biochemistry
Abbreviations AAV: Adeno-associated virus AFM: Atomic force microscopy AMD: Age-related macular degeneration AmpB: Amphotericin B ASO: Antisense oligonucleotide aV: Anti-VEGF antibodies BAB: Blood-aqueous barrier BetP: Betamethasone phosphate Bev: Bevacizumab BRB: Blood-retinal barrier BT: Brimonidine tartrate CIP-NE: Ciprofloxacin-loaded nanoemulsion CNV: Choroidal neovascularization CsA: Cyclosporine A CSO-VV-SA: Chitosan oligosaccharide-valylvaline-stearic acid CS-PLGA NPs: Chitosan-coated polylactide-glycolic acid nanoparticles DED: Dry eye disease Dex-NW: Dexamethasone-loaded nanowafer DHPs: Dendrimer gel hydrogel particles DLS: Dynamic light scattering DR: Diabetic retinopathy D-TA: Dendrimer-triamcinolone acetonide EV: Extracellular vesicle EXO: Exosome FDA: Food and drug administration FF-TEM: Freeze-fracture transmission electron microscopy FK: Fungal keratitis HA: Hyaluronic acid HA-LIP: Liposomes coated with hyaluronic acid HCO-40/OC-40: Hydrogen-castor oil 40/octyl alcohol 40 HDR: Homology-directed repair IOP: Intraocular pressure IVT: Intravitreal injection MEL: Melatonin MEs: Microemulsions MGO: Methylglyoxal MNs: Microneedles MOX-PAM: Moxifloxacinpamoate MSC-exo: Exosomes derived from mesenchymal stromal cells NaMESys: Nanostructured microemulsions system NaMESys-SOR: NaMESys carrying sorafenib nEPC: Copolymer EPC nEPCs + A: Aflibercept loaded nEPCs NEs: Nanoemulsions NHEJ: Non-homologous end joining mechanisms NPs: Nanoparticles NS: Nanosuspension NS-TEM: Negative staining transmission electron microscopy O/W: Oil-in-water ODDS: Ocular drug delivery systems PCL: Polycaprolactone PDI: Polydispersion index PEG: Polyethylene glycol PLA: Polylactic acid PLGA: Polylactide-coglycolide, PUTK: Thioketal-containing polyurethane PVA: Polyvinyl alcohol rEXS: Exosomes derived from regulatory Treg cell RH: Reactive oxygen -scavenging hydrogel rMMNs: Redox-responsive quasi-mesoporous magnetic nanospheres SEM: Scanning electron microscopy shRNA: Short hairpin RNA siRNA: Small interfering RNA SNEDDS: Self-nano emulsifying drug delivery systems SPM: Self-plug-type microneedle TA: Triamcinolone acetonide TEM: Transmission electron microscopy TPGS: Tocopherol polyethylene glycol 1000 succinate VEGF: Vascular endothelial growth factor W/O: Water-in-oil ZP: Zeta potential References Ma Y, Bao J, Zhang Y, et al
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Phagocytosis in the brain: Homeostasis and disease
