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4 Pharmacokinetic properties A full understanding of its behavior in biological systems, essential for further caudatin development as a clinical agent, can only be achieved since the pharmacokinetic (PK) profile determines absorption, distribution, metabolism, and elimination (ADME), and parameters that control both safety and efficacy ( Quantitative characterization of the caudatin PK profile has been primarily derived from studies in rats, and particularly those that have successfully quantified using sensitive UPLC-MS/MS technology (Zhu et al., 2015) with a linear range established from 2.5 to 300 ng/mL in rat plasma

The mechanism of action of AGE was only investigated in two cell lines (HaCaT and SCC7)

TGF-beta1 and angiotensin networking in cardiac remodeling

Avoid temptation increasing dose or frequency thinking "more is better." Stable effective protocol through completion then reassess need for continued treatment versus tapering