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However, he added that since many of these experimental peptides dont have the same robust catalog of clinical trial data as FDA-approved medications, evaluating them for the 503A Bulks List may prove challenging for the committee and the agency

For example, the tryptophan catabolite pathway is significantly more active in women than in men, thereby increasing the production of neurotoxic catabolites [225]

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181 These findings strongly suggest that the Rho/ROCK pathway is a therapeutic target for restoring disrupted intestinal tight junctions