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Cigarette smoke can reduce the expression of Frizzled receptor 4 (FZD4) in alveolar epithelial cells and enhance the phosphorylation of -catenin, inhibiting epithelial proliferation and alveolar repair mediated by the classic Wnt signalling pathway

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Right ventricular pressures were measured with a high-fidelity pressure catheter inserted in the right ventricle via cannulation of the right jugular vein, to monitor the development of pulmonary hypertension