glutathione antioxidant enzyme system Effect of nitrite exposure on the enzymes and in the liver of bighead carp, Aristichthys nobilis Glutathione system enhancement for cardiac

Norman Peter Andrew Huner, Western University, Canada Copyright 2015 Masi, Trentin, Agrawal and Rakwal

Nat Commun 12(1):2594

Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis

32:681-687 [PubMed: 27736021] 249

Conclusion Our study found that in WD, the function of the HPT axis is impaired, and copper deposition may be related to the inhibition of phosphorylation of ERK 1/2 signaling pathway and the promotion of expression of downstream pro-apoptotic proteins Bax and Caspase-3, as well as the inhibition of expression of anti-apoptotic protein Bcl-2, leading to an increased apoptosis of hypothalamus neurons and pituitary cells