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catalase or the catalytic activity of GSH H2O2 would accumulate, eventually producing highly injurious hydroxyl radicals ( )

Acknowledgements The authors thank the finantial support from FAPESP, Fundao de Amparo Pesquisa do Estado de So Paulo (grant number: 2025/28627-4), CAPES, Coordenao de Aperfeioamento de Pessoal de Nvel Superior (grant number 88887.991854/2024-00, recipient JMS), and CNPq, Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (grant number 308164/2022-9, recipient ACS)

Cultures were then incubated at 30 or 37 C while rotating

Attention has now shifted to its potential as an immune and inflammatory modulator

The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug resistance, and activation of host immune response