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Phase II takes these highly reactive, dangerous intermediates and binds (conjugates) them to endogenous molecules to neutralize them

As mitochondria are the primary source of ROS, their function could be compromised by excessive antioxidants

Cochrane Database Syst Rev 4:CD006612 Mei W, Rong Y, Jinming L, Yongjun L, Hui Z (2010) Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials

78 Although ALDH1L1 is overexpressed in NSCLC and GC cancer, 79,80 ALDH1L1 is reported profoundly downregulated or silenced in cancers, rendering it a candidate tumor suppressor

IV therapy can be safe when trained healthcare professionals use the appropriate equipment and follow established protocols