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High levels of ROS play a dual role in bone metabolism: ROS promote the differentiation and activity of osteoclasts by activating osteoclast-related signaling pathways, thereby accelerating bone resorption and leading to bone loss

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Metformin (Mt) or combined oral contraceptive pills (COCPs) should be chosen based on symptoms taking into account the biochemical advantages of combination therapy that targets the two main endocrine disorders associated with PCOS (hyperandrogenism and hyperinsulinemia) [15]

However, the hypothesis that restoring gut health could play a key role in managing ME/CFS emphasizes the importance of integrating microbiome research into current therapeutic frameworks, thereby advancing the understanding and treatment of this complex and multifaceted condition [1]