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Selenium - a fascinating antioxidant of protective properties

PA can protect APAP-induced liver injury via alleviating oxidative stress and mitochondrial dysfunction by affecting the nuclear migration of Nrf2 via inhibiting Keap1 (Zhou et al., 2023)

Peroxides reduction Protein SS groups reduction and Protein/GSH adducts cleavage Glutaredoxin GSSG cholesterol synthesis cholesterol synthesis and GSSG Glutathionylation Glutathionylation: a regulatory role of glutathione in physiological processes, 2018 Direct and indirect regulatory roles in physiological processes include glutathionylation of: major transcriptional factors, eicosanoids, cytokines, nitric oxide (NO) Which is the information content of GSH molecule

If hepatic support is the goal, NAC (600mg twice daily) paired with adequate hydration and alcohol avoidance is the evidence-based approach

2022 Oct 3;62(28):7827-48