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Phosphorus demand also increases under light stress to sustain ATP production, photoprotective mechanisms, and repair processes, whereas phosphorus limitation exacerbates photooxidative damage

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Due to their preclinical testing and lack of comparison with other dual receptor agonists such as tirzepatide, further studies are needed to determine whether the effects of these unimolecular compounds are superior to those of clinically tested drugs

SIRT1, SIRT3, SIRT6, and SIRT7 are directly involved in normal bone development and homeostasis by regulating OBs (Figure 4)