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Key events in this pathway include the disruption of MMP, the release of cytochrome c, and the activation of caspases

10.1038/mp.2011.52 Mol

10.1002/eji.200324143 27

Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO-1 signaling, the microbiota-gut-brain axis, and hippocampal neuron ferroptosis

Through technological innovations (CRISPR screening for resistance targets, real-time death process monitoring via nanoprobes) and adaptive clinical trial designs (basket trials stratified by ACSL4 activity), the vision of on-demand death induction tailored to individual molecular profiles is advancing, heralding a new era of precision oncology with transformative potential for global cancer care (Table 5)