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Adding cagrilintide at a moderate dose (1.0-2.4 mg) provides amylin-mediated appetite suppression through a completely different neuronal circuit, which may allow you to use a lower retatrutide dose (8 mg instead of 12 mg) while achieving comparable or superior total metabolic effect

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3), including H-bonds with the backbone of S129 ECD , and hydrophobic interactions with D77 ECD , G78 ECD , W79 ECD , Y131 ECD and W128 ECD , consistent with interactions also formed by Pro32 of sCT