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Meng et al., 2015)

The prevailing model for NRF2-dependent target gene expression involves the binding of NRF2 to ARE sequences within proximal promoters of specific target genes (Tonelli et al, 2018)

Paeoniflorin significantly increased melanin content and intracellular TYR activity of human melanocytes by regulating the ERK/CREB pathway, and improved monobenzone-induced vitiligo in mice [82]