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The progression makes the disease even more deadly

Romero A, Ramos E, de Los RC, Egea J, Del Pino J, Reiter RJ (2014) A review of metal-catalyzed molecular damage: protection by melatonin

Autophagy can modulate the expression and activity of apoptosis-related proteins, thereby indirectly altering cellular susceptibility to ferroptosis (38)

Targeted therapies, including TNF- inhibitors and IL-6 receptor antagonists, effectively reduce inflammation and improve outcomes through cytokine blockade (Smolen, 2020)