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Meanwhile, a newly proposed type of cell death, ferroptosis, has been demonstrated to be closely related to the GSH system, which affects the process and outcome of myocardial injury

It promotes lipolysis , the breakdown of triglycerides into free fatty acids used for energy, aiding in reductions in body fat percentage (Yaspelkis & Ivy, American Journal of Physiology )

The strong GSH efflux induced by verapamil is energy dependent since MRP1 K1333L, a mutant with a defective ATPase activity, is unable to confer CS in cells overexpressing it 12