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Description

The data are presented as heatmaps of z-score normalized abundances for the significantly different metabolites across all groups (Fig

3.1.2 Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a metabolic disorder typically caused by mtDNA mutations in tRNA genes, predominantly by the A3243G mutation in the MT-TL1 gene, encoding for tRNA-Leu(UUR) (Yu-Ichi et al., 1990