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In this context, key animal model studies by Cao et al

Nat Genet (2014) 46:2619.10.1038/ng.2875 124 HarnettWWormsMJKapilAGraingerMParkhouseRME

For instance, L-arginine is metabolized by arginase to produce L-ornithine, a precursor for both polyamines and L-prolinetwo metabolite groups intimately associated with fibrosis