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138 NAMPT has an important role in the tumorigenic microenvironment in leukemia, with eNAMPT playing an important role in macrophage differentiation to the M2 phenotype and polarization in tumorigenesis-associated macrophages

This cell-to-cell adhesion is translated into intracellular signaling pathways [37], culminating in specific alterations within the cell, at the cytoplasmatic level