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Although the successful application of TyU19 and KYV-201 in IMIDs encourages the further exploration of allogeneic CAR-T therapy in patients with severe and refractory IMIDs (120), the optimal timing for allogeneic CAR-T therapy in autoimmunity requires further investigation due to the potential unknown short- and long-term safety risks and toxicity associated with off-the-shelf CAR-T therapies (150152)

Third, vaccine-based strategies targeting senescence-specific surface markers, such as CD153 or glycoprotein nonmetastatic melanoma protein B (GPNMB), offer a scalable approach for sustained senescent cell clearance

These responses can range from the release of hormones to the activation of enzymes or proteins

Cancer 2022, 22, 557