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In the former, fine-tuning of glutaredoxin activity 41 allows for a high frequency of disulphide bonding to occur and several instances of selenylsulphide bonding 42

Tirzepatide may be considered for individuals not at target on basal insulin with the aim of improving glycaemic control, decreasing weight and minimising risk of hypoglycaemia [12] (Table 2, clinical scenario B)