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DOI: 10.1016/j.regpep.2009.11.012.

Each peptide was scored using weighted criteria: Clinical Evidence (40%) based on peer-reviewed studies, Safety Profile (25%) from adverse event data, Cost-Effectiveness (20%) comparing monthly treatment costs, and Accessibility (15%) considering prescription requirements and availability through physician-supervised clinics

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Among them, GPX4 is a membrane-associated phospholipid hydroperoxidase, and it is also the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides, which can reduce complex lipid compounds in addition to reducing H 2 O 2 and small molecule hydroperoxides