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The authors suggest that adequate vitamin B6 levels may avert psychological distress during emotional situations, such as grieving, by regulating serotonin levels.[47] Cardiovascular Support Elevated levels of homocysteine have been identified as an independent risk factor for coronary artery disease.[48] Independent of its place in the methylation cycle, evidence also suggests that homocysteine is in itself a toxic compound that can directly promote atherosclerosis, neuronal damage and mood disturbances.[49] Therefore, hyperhomocysteinaemia is not only a marker of reduced methylation status, but also a direct pathogenic agent

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Bone marrow mesenchymal stem cell (BMSC)-derived EVs modified with an integrin -targeting peptide were found to enhance the efficacy of therapeutic regimens targeting pancreatic cancer by promoting the reprogramming of cancer-associated fibroblasts (CAFs) while inhibiting the pro-carcinogenic effects [62]