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At the oxidative stress level, excessive generation of ROS and antioxidant system imbalance have been observed to not only directly damage intestinal mucosal cells but also to influence immune cell differentiation and barrier repair through modulation of signaling pathways, thereby creating a vicious cycle of inflammatory progression [12, 29]

Published 2021

Given the complexity of targeting neural receptors, future studies in our lab will aim at examining whether long-term peripheral administration of MTII, a more translational approach for humans, would yield similar physiological responses

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