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Public clinical trials have monitored adverse events and safety outcomes under controlled protocols

Zhang CE, Wei W, Liu YH et al (2009) Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain

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Together, these enzymes are essential components of the two systems that regulate the cellular redox state and other diverse biological processes through thioredoxin and glutathione

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