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1315 Where tissue preservation is paramount (lip, lower eyelid and inner canthus of the eye), for bony or cartilaginous sites and in patients for whom surgery is contraindicated, radiotherapy is often the treatment of choice

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Drugs with a Vd value of less than 0.3 L/kg are predominantly confined to the ECF, whereas drugs with a Vd value of greater than 1 L/kg are highly lipid soluble and tend to distribute out of the extracellular fluid and into tissue compartments (Box 4-1)

High levels of UTP suppress the production of pyrimidines, ensuring balance with other nucleotide pools