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The oral route is particularly relevant for gastrointestinal applications because it delivers the peptide directly to the tissues where it is needed

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As the literature expands on the links between gut dysbiosis and the broader symptomatology of ME/CFS, it becomes increasingly necessary to integrate this knowledge into clinical practice, reinforcing perspectives that prioritize holistic treatment methodologies in an often fragmented care landscape

Because B12 is water-soluble, there is no toxicity

10.1016/j.actbio.2021.11.044 211 ZhuC.LiJ.LiuC.ZhouP.YangH.LiB