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The first study ex vivo in Ussing chambers (1999) evaluating the epithelial barrier function in colonic tissue from UC patients with mild or moderate macroscopic disease activity showed a 50% decrease of the total electrical wall resistance (assessed by transmural impedance analysis) when compared to healthy subjects

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Despite promising findings, several key challenges remain in cuproptosis researchi:is there a specific threshold of copper concentration that determines whether a cell will experience toxicity or undergo cuproptosis?The relationship between cytotoxicity and cuproptosis: are they complementary, or does one promote the other

Selenoproteins guard against oxidative stress primarily by constraining reactive oxygen species (ROS) and reactive nitrogen species (RNS) [147]

Mouse models have been used to directly examine the contribution of MPO to atherosclerosis, although these studies carry the caveat that mouse MPO levels are only 10-20% that of humans (286,287)