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Haematological symptoms typically appear first and include fatigue, weakness, and pallor due to megaloblastic anaemiaa condition where the bone marrow produces abnormally large, immature red blood cells that function poorly

In vivo and in vitro models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expression of genes related to glutathione anabolic metabolism (GCLC, GCLM, and SLC7A11) was significantly down-regulated

Researchers examining potential neurological or cognitive effects often prefer the nasal route because it provides more direct access to the central nervous system

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Regulation of NF-B by TNF family cytokines