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At the joint microenvironment level, analyses of synovial fluid and cartilage tissue samples from OA patients, as well as studies in surgically induced such as the DMM model or chemically induced animal OA models, consistently observe clear iron metabolism abnormalities and significant iron accumulation locally in affected joints

Entacapone also exhibited anti-ferroptosis activity to alleviate IRI-induced renal damage and pathological changes in mice and erastin- or RLS3-induced lipid peroxidation and iron accumulation

Consequently, the IL-23/Th17 axis has emerged as one of the premier therapeutic targets (e.g., IL-23p19 inhibitors) (Samarani et al., 2020)

( A ) Inflammation: During the various stages of wound healing, cytokines are involved in fluctuating concentrations to regulate the process

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