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Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

During the 1990s, casecontrol studies were performed utilizing MDD based on the DSM or ICD criteria as the independent variable, with biomarkers serving as the dependent variables

Each component underwent Phase I/II clinical trials but did not proceed to further development

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