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WE-EF-BRA-05: Experimental Design for High-Throughput In-Vitro RBE Measurements Using Protons, Helium and Carbon Ions

Notably, the accumulation of genetic mutations (e.g., point mutations, inversions, translocations, deletions, and polyploidy) drives the malignant transformation of cancer cells and facilitates the acquisition of cancer-specific hallmarks, including cell immortality, apoptosis inhibition, drug resistance, angiogenesis, invasiveness, and the activation of metastatic processes [3,4,5,6]

Evidence (sorafenib): A phase III, randomized, double-blind, placebo-controlled study (DECISION [NCT00984282]) evaluated the activity of sorafenib in patients with progressive, iodine-refractory, differentiated thyroid cancer.[21] The trial included 417 patients with locally advanced or metastatic RAIrefractory thyroid cancer (papillary, follicular [including Hrthle cell], and poorly differentiated, not anaplastic tumors, defined as beyond well-differentiated tumors or those well-differentiated tumors that become resistant to radioiodine treatment) whose disease had progressed within the past 14 months

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extracts, such correlation is not clear