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Ag II-induced ferroptosis was detected in astrocytes [424], vascular endodthelial cells [357], and cardiomyocytes [425]

One possible hypothesis is based on the ability of the SARS-CoV-2 virus to cross the blood-brain barrier and reach the brain, or that the virus may reach the brain via the hematogenous route 11

Additionally, it has been demonstrated that both modification on KEAP1 at cysteine 151 and PKC-delta-mediated NRF2 phosphorylation are required for the release of NRF2 from KEAP1 [12]