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Billon C, Appourchaux K, et al

In summary, the key interactions to consider are pyridoxines reduction of levodopa and anticonvulsant efficacy, niacinamides additive effects on blood pressure, blood sugar, and gout management, and the potential need for B-vitamin repletion in patients on certain medications (diuretics, isoniazid, etc.)

Physicians may check levels in children who are growing slowly, or when pituitary disorders or tumors are suspected

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