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In addition, KD enhances translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and increases expression of glutathione peroxidase and heme-oxygenase-1 in an AD mouse model, suggesting activation of Nrf2-dependent antioxidant responses in this experimental context

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Recently propofol, an intravenous anesthetic with anti-neuroinflammatory properties, was shown to mitigate induced oxidative damage in BV-2 cells (Peng et al., 2020)

Conclusion These findings suggest a mechanism by which GYY4137 through redox modification of p65 participates in inhibiting NLRP3 activation by OA to regulate inflammatory responses

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