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Studies indicate that EDA may improve corticosterone-induced depression-like behavior in mice by modulating the Fkbp5, Comt, Adora1, and Slc6a15 genes ( Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are essential components of Omega-3 PUFAs (n-3-PUFAs), known to improve depression by reducing inflammation and enhancing the expression of neurotrophic factors (PENG et al., 2020)