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Menadione, which lacks an aliphatic sidechain, also rescued cells from ferroptosisalbeit with lower efficacywhereas dimethylmenadione, a redox-inactive form, did not prevent ferroptosis (Extended Data Fig

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Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance

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The inconsistency likely arises from differences in experimental conditions, such as pH, Cu+/Cu2+ ratio, A isoform, and the presence of reducing agents or cofactors (190)