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However, such information is important as it could help identify individuals who may be suitable for future MedDiet interventions and help optimise the design of studies hoping to increase adherence to this dietary pattern in athletes

Geng Z, Huang J, Kang L, Gao S, Yuan Y, Li Y, et al

Lipidomic analysis, coupled with functional metabolic assays, showed that FADS1/2 high-expressing TNBC are susceptible to ferroptosis-inducing agents and that targeting FADS1/2 by both genetic interference and pharmacological approach renders those tumors ferroptosis-resistant while unbalancing PUFA/MUFA ratio by the supplementation of exogenous PUFA sensitizes resistant tumors to ferroptosis induction

For example, in non-small cell lung cancer, the KRAS G12D mutation is associated with resistance, and through scRNA-seq and bioinformatics analysis, it was found that cell subpopulations with different KRAS expression levels respond differently to drugs

Arginase inhibition improves endothelial function in an age-dependent manner in healthy elderly humans