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Consistent with this, the observation of reduced viability of H9c2 cardiomyoblasts and HUVEC endothelial cells to values below 80% when incubated with GSNO concentrations above 75 m and 156 m, respectively, indicates that the cytotoxic effect of high GSNO concentrations, such as 500 m, may prevail over the beneficial effect of cardioprotection in I/R

Kumar A, Majeti NV (2014) Proteomic responses to lead-induced oxidative stress in Talinum triangulare Jacq

These different mechanisms lead to different outcomes and risks

A study involved 60 PD patients with dopamine-resistant tremor ( n = 17), dopamine-responsive tremor ( n = 23), or no tremor ( n = 20), and healthy controls ( n = 22) showed that GABA level was unchanged in PD patients compared to the controls

References 1 YangHLinJLiHLiuZChenXChenQ