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More research is needed before these combinations can be recommended as evidence-based treatments

is a membranebound enzyme that preferentially catalyzes the methylation of aliphatic sulfhydryl compounds such as captopril and Dpenicillamine, whereas is a cytoplasmic enzyme that preferentially catalyzes the methylation of aromatic and heterocyclic sulfhydryl compounds including anticancer and immunosuppressive thiopurines such as 6mercaptopurine, 6thioguanine, and azathioprine

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Harris ML, Schiller HJ, Reilly PM, Donowitz M, Grisham MB, and Bulkey GB (1992)

Proteins (100+ amino acids): Regulated as Biologics, which face the strictest federal oversight and generally cannot be compounded