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Integrating structure-based approaches in generative molecular design

[Abstract] Biomed Pharmacother

B.TXNIP plays a central role in negative regulation of glucose metabolism TXNIP is another component of the TRX1 system, negatively regulating TRX1 function by inhibiting reduced TRX through intermolecular disulfide bond interactions 150,151

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This pathway is the main quantitative route for endogenous glycine production in humans and is particularly active in tissues with high metabolic rates and demands for nucleotide synthesis, such as the liver and central nervous system