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Given the crucial roles of folate and vitamin B12 in DNA synthesis, deficiencies of these vitamins can lead to impaired DNA synthesis, which may contribute to disruptions in cell proliferation, differentiation, and function

Rubio Gomez, M

H., Liu, H

Furthermore, the expansion of pathobionts like Peptostreptococcus can generate detrimental metabolites (e.g., indole derivatives), which directly upregulate cartilage-degrading MMP-13 (2628)