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The disease often follows a protracted course, substantially impairing quality of life and imposing a significant healthcare burden (Segal et al., 2021

B.Mandarim-de-LacerdaC

Recent findings It is now recognized that intestinal permeability reflects the combined effects of two distinct routes across tight junctions, which form selectively permeable seals between adjacent epithelial cells, and mucosal damage that leads to nonselective barrier loss