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As presented in Figure 6E and Table 7 , in the negative mode, compared with the LPS group, the MCE+LPS group had 10 up-regulated metabolites (Gamma-Glutamylthreonine, D-altro-D-manno-Heptose, N-acetylaspartate, (1R,2S,3S,4R)-p-Menthane-2,3-diol, Stearic acid, Threoninyl-Tyrosine, L-Ribulose, L-Aspartic Acid, L-Glutamate and Myo-Inositol) and 5 down-regulated metabolites (TXB2, Lamivudine sulfoxide, Ribothymidine, 6-(3-ethenylphenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid and 5-Methoxynoracronycine)
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Keywords : Pain, IGF/IGF-1R pathway, Neuronal excitability, Neuroinflammation, Glial cell Pain is a complex biopsychosocial phenomenon, which is redefined as an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage by the International Association for the Study of Pain (IASP) in 2020[1]