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Are you looking to lose weight and are B12 deficient

If your stomach struggles to produce enough stomach acid, injections are much better than oral supplements due to their bioavailability

Because correction of the underlying metabolic disorder generally results in correction of acid-base abnormalities and because of the potential risks of sodium bicarbonate therapy in the treatment of this disorder, administration of sodium bicarbonate is generally reserved for the treatment of severe acidosis (e.g., arterial pH less than 7-7.15 or serum bicarbonate concentration of 8 mEq/L or less)

A research guide to the component mechanisms and the co-administration rationale

Researchers studying metabolic stress often pair this combo with SS-31 (Elamipretide), which targets mitochondrial function and oxidative stress pathways