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Finally, as mentioned above, some cellular systems have evolved -catenin signaling mechanisms that are primarily driven by clustered Dishevelled rather than FZD and Wnts 102

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Most clinically approved antifungal drugs target either fungal cell walls (chitin, glucan and mannan) or cell membrane (ergosterol)-associated entities, as they are essential for fungal survival and growth, but not necessary for the host [131, 144]