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Leukemia 34:317321 Horenstein A, Quarona V, Toscani D, Costa F, Chillemi A, Pistoia V et al (2016) Adenosine generated in the bone marrow niche through a CD38-mediated pathway correlates with progression of human myeloma

However, these effects have not been firmly established in large human clinical trials

If the nodule is definitively benign at surgical pathological exam and the remainder of the thyroid is normal, lobectomy or more limited resection is performed