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In the landmark UK Prospective Diabetes Study (UKPDS) , metformin use in overweight patients with type 2 diabetes significantly reduced diabetes-related endpoints, myocardial infarction, and all-cause mortality compared with conventional therapy, effects that persisted on long-term follow-up (Lamanna et al., 2011

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As an example, prostate cancer and diffuse large B-cell lymphoma, use FAO as the main source of energy and express FAO enzymes at high levels (Liu, 2006

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